NPS R-568 halts or reverses osteitis fibrosa in uremic rats
نویسندگان
چکیده
منابع مشابه
Pharmacological activity of calcimimetic NPS R-568 administered intravenously in rats: dose dependency.
Calcimimetics administered orally cause "pharmacological parathyroidectomy" confirmed by a decrease in parathyroid hormone secretion (PTH) and in plasma Ca(2+) concentration. Parathyroids are also the source of parathyroid hypertensive factor (PHF). The aim of this study was to determine the dose-dependent effect of an intravenously (iv) applied calcimimetic, NPS R-568, on plasma Ca(2+) concent...
متن کاملCalcimimetic R-568 decreases extraosseous calcifications in uremic rats treated with calcitriol.
Calcimimetics decrease parathyroid hormone (PTH) levels in uremic patients with secondary hyperparathyroidism without increasing serum calcium (Ca). The aim of this study was to evaluate the effect of calcimimetic R-568 alone or in combination with calcitriol on vascular and other soft tissue calcifications in uremic rats with secondary hyperparathyroidism. Sham-operated and 5/6 nephrectomized ...
متن کاملCalcimimetic compound NPS R-568 stimulates calcitonin secretion but selectively targets parathyroid gland Ca(2+) receptor in rats.
N-(3-[2-Chlorophenyl]propyl)-(R)-alpha-methyl-3-methoxybenzylamine (NPS R-568) is an orally active compound that activates Ca(2+) receptors on parathyroid cells and rapidly suppresses plasma levels of parathyroid hormone (PTH) and Ca(2+) (ED(50), 1 and 10 mg/kg, respectively). We now show that increased calcitonin secretion contributes to NPS R-568-induced hypocalcemia. In parathyroidectomized ...
متن کاملOsteitis Fibrosa Cystica Mistaken for Malignant Disease
A 65-year-old man with back pain had plain radiographs that showed multiple osteolytic bone lesions of the pelvis, femur and L-spine; an magnetic resonance imaging scan of the L-spine showed extensive bony resorption with a posterior epidural mass involving the L1 spinous process; these findings suggested multiple myeloma or bony metastasis. However, all serology testing was negative. The parat...
متن کاملGeneralized Osteitis Fibrosa with Parathyroid Adenoma
or disseminated sclerosis but I was told that she had had some pain around the groin, that her doctor had sent her for X-ray of the pelvis, and that a large destructive lesion had been found in one of the pubic rami. A surgeon saw her and advised that she should be admitted to a chronic hospital: the diagnosis was secondary tumours of bone. When I first looked at this X-ray picture of the pubis...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1998
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.1998.00782.x